Article

Methylation-mediated retuning on the enhancer-to-silencer activity scale of networked regulatory elements guides driver-gene misregulation

2021-03-03

Abstract excerpt

Cancers arise when particular disease-driving genes adopt abnormal functions, but analyses of coding and regulatory sequences leave many of these abnormalities unexplained. We developed a strategy to explore alternations in the regulatory effects of silencers and enhancers in cancer tumors. Applying the method to 177 gene regulatory domains in human glioblastomas, we produced a driver-gene wide dataset of gene-ass...

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Literature Corpus work: d3888e70-096c-51d5-924e-2486883a6ec3
DOI: 10.1101/2021.03.02.433521

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