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Article

Pooled single-cell screen in colorectal cancer defines transcriptional modules linked to oncogenes.

Molecular systems biology - 1 Mar 2026

Hollek Viola, Böhning Francisca, Florez Vargas Catalina, Sieber Anja, Morkel Markus, Blüthgen Nils

Abstract excerpt

Oncogenic mutations shape colorectal cancer (CRC) biology, yet their impact on transcriptional phenotypes remains incompletely understood, and their individual prognostic value is limited. Here, we perform a pooled single-cell transcriptomic screen of over 100,000 CRC cells with a comprehensive barcoded library of oncogenic variants across genetically diverse CRC lines. Using a variational autoencoder-based...

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Identifiers

PMID: 41555096
DOI: 10.1038/s44320-025-00186-2
PMCID: PMC12954089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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