Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer.

doi:10.1158/1055-9965.EPI-21-0724

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Article

Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 4 May 2022

Barfield Richard, Huyghe Jeroen R, Lemire Mathieu, Dong Xinyuan, Su Yu-Ru, Brezina Stefanie, Buchanan Daniel D, Figueiredo Jane C, Gallinger Steven, Giannakis Marios, Gsur Andrea, Gunter Marc J, Hampel Heather, Harrison Tabitha A, Hopper John L, Hudson Thomas J, Li Christopher I, Moreno Victor, Newcomb Polly A, Pai Rish K, Pharoah Paul D P, Phipps Amanda I, Qu Conghui, Steinfelder Robert S, Sun Wei, Win Aung Ko, Zaidi Syed H, Campbell Peter T, Peters Ulrike, Hsu Li

Abstract excerpt

BACKGROUND: Colorectal cancer has a strong epigenetic component that is accompanied by frequent DNA methylation (DNAm) alterations in addition to heritable genetic risk. It is of interest to understand the interrelationship of germline genetics, DNAm, and colorectal cancer risk. METHODS: We performed a genome-wide methylation quantitative trait locus (meQTL) analysis in 1,355 people, assessing the pairwise...

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Identifiers

PMID: 35247911
DOI: 10.1158/1055-9965.EPI-21-0724
PMCID: PMC9081265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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