Article
Integrating muti-omics data to identify tissue-specific DNA methylation biomarkers for cancer risk.
Nature communications - 18 Jul 2024
Yang Yaohua, Chen Yaxin, Xu Shuai, Guo Xingyi, Jia Guochong, Ping Jie, Shu Xiang, Zhao Tianying, Yuan Fangcheng, Wang Gang, Xie Yufang, Ci Hang, Liu Hongmo, Qi Yawen, Liu Yongjun, Liu Dan, Li Weimin, Ye Fei, Shu Xiao-Ou, Zheng Wei, Li Li, Cai Qiuyin, Long Jirong
Abstract excerpt
The relationship between tissue-specific DNA methylation and cancer risk remains inadequately elucidated. Leveraging resources from the Genotype-Tissue Expression consortium, here we develop genetic models to predict DNA methylation at CpG sites across the genome for seven tissues and apply these models to genome-wide association study data of corresponding cancers, namely breast, colorectal, renal cell, lung,...
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