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Mapping the landscape of cell type-dependent genetic regulation of DNA methylation across human tissues

2025-11-07

Abstract excerpt

<title>Abstract</title> <p>DNA methylation (DNAm) is an epigenetic modification involved in gene regulation. DNAm quantitative trait loci (mQTLs) have been identified in many tissues, but bulk-tissue studies obscure cell type-specific effects. Here, we present the first multi-tissue landscape of cell type-dependent regulation of DNAm in humans by mapping cell type-interaction mQTLs (imQTLs) across seven tissue ty...

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Literature Corpus work
8a0c8bcf-448a-562d-88b3-60a6246bbd40
DOI
10.21203/rs.3.rs-7895550/v1
Open publication

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Mapping the landscape of cell type-dependent genetic regulation of DNA methylation across human tissuesDOI 10.21203/rs.3.rs-7895550/v1
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