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Genomic and Epigenomic Integration Identifies a Prognostic Signature in Colon Cancer

29 Jan 2011

Abstract excerpt

PURPOSE: The importance of genetic and epigenetic alterations maybe in their aggregate role in altering core pathways in tumorigenesis. EXPERIMENTAL DESIGN: Merging genome-wide genomic and epigenomic alterations, we identify key genes and pathways altered in colorectal cancers (CRC). DNA methylation analysis was tested for predicting survival in CRC patients using Cox proportional hazard model. RESULTS: We...

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Share to Colorectal Cancer Treatments and Studies
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PMID: 21278247
DOI: 10.1158/1078-0432.ccr-10-2509

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