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Article

Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation.

Genome biology - 28 Nov 2023

Edrei Yifat, Levy Revital, Kaye Daniel, Marom Anat, Radlwimmer Bernhard, Hellman Asaf

Abstract excerpt

BACKGROUND: Common diseases manifest differentially between patients, but the genetic origin of this variation remains unclear. To explore possible involvement of gene transcriptional-variation, we produce a DNA methylation-oriented, driver-gene-wide dataset of regulatory elements in human glioblastomas and study their effect on inter-patient gene expression variation. RESULTS: In 175 of 177 analyzed gene...

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Identifiers

PMID: 38012713
DOI: 10.1186/s13059-023-03094-6
PMCID: PMC10683314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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