Article

Molecular basis of enfumafungin inhibition and resistance in <i>Candida glabrata</i> β-1,3-Glucan synthase FKS1

2026-02-08

Abstract excerpt

β-1,3-Glucan synthase FKS1 is essential for fungal cell wall biogenesis and serves as a validated target of widely prescribed antifungal drugs. However, the molecular mechanism of pathogenic FKS1, its modes of inhibition, and the associated resistance mechanisms remain elusive, hindering the antifungal development. Here, we focus on Candida glabrata FKS1, a clinically relevant target frequently linked to antifung...

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Literature Corpus work: 3792e945-8f9c-5dc0-b3ef-018b1bd7c410
DOI: 10.64898/2026.02.07.704550

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