Article

The SAGA and NuA4 component Tra1 regulates <i>Candida albicans</i> drug resistance and pathogenesis

2021-03-18

Abstract excerpt

Candida albicans is the most common cause of death from fungal infections. Emergence of resistant strains reducing the efficacy of first line therapy with echinocandins such as caspofungin calls for the identification of alternative therapeutic strategies. Tra1 is an essential component of the SAGA and NuA4 transcriptional co-activator complexes. As a PIKK family member, Tra1 is characterized by a C-terminal phosp...

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Literature Corpus work: 28ee02eb-c2de-53ff-bf74-f32804b6493a
DOI: 10.1101/2021.03.17.435915

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