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Article

Mutational landscape and molecular bases of echinocandin resistance in Saccharomyces cerevisiae.

Genetics - 6 May 2026

Durand Romain, Torbey Alexandre G, Giguere Mathieu, Pageau Alicia, Dubé Alexandre K, Lagüe Patrick, Landry Christian R

Abstract excerpt

One of the front-line drug classes used to treat invasive fungal infections is echinocandins, which target the fungal-specific beta-glucan synthase (Fks). Treatment failure due to resistance often coincides with mutations in 3 protein regions defined as hotspots. Unfortunately, the scarcity of the mutational data reported, combined with the large size and membrane-embedded nature of the enzyme hinder any effort...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41766466
DOI: 10.1093/genetics/iyag055
PMCID: PMC13147539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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