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Characterization of a Novel <i>FKS1</i> Mutation in <i>Candida lusitaniae</i> Shows a Potential Critical Role for <i>MKC1</i> in Echinocandin Resistance

2025-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Caspofungin is an echinocandin antifungal that inhibits glucan synthesis in the fungal cell wall. A Candida parapsil osis bloodstream isolate resistant to echinocandins was recovered from a patient who had undergone allogeneic hematopoietic stem cell transplantation. The FKS1 gene, encoding the target glucan synthase, contained a heterozygous mutation resulting in an I1380T amino acid change,...

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Literature Corpus work
a2eb7c60-7ea6-5ebd-badd-cce527ae7a46
DOI
10.1101/2025.04.08.647726
Open publication

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Characterization of a Novel <i>FKS1</i> Mutation in <i>Candida lusitaniae</i> Shows a Potential Critical Role for <i>MKC1</i> in Echinocandin ResistanceDOI 10.1101/2025.04.08.647726
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