Article
Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis.
PLoS pathogens - 1 Sept 2024
Hassoun Yasmine, Aptekmann Ariel A, Keniya Mikhail V, Gomez Rosa Y, Alayo Nicole, Novi Giovanna, Quinteros Christopher, Kaya Firat, Zimmerman Matthew, Caceres Diego H, Chow Nancy A, Perlin David S, Shor Erika
Abstract excerpt
Invasive fungal infections are associated with high mortality, which is exacerbated by the limited antifungal drug armamentarium and increasing antifungal drug resistance. Echinocandins are a frontline antifungal drug class targeting β-glucan synthase (GS), a fungal cell wall biosynthetic enzyme. Echinocandin resistance is generally low but increasing in species like Candida glabrata, an opportunistic yeast...
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