Article
Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1.
Nature - 1 Apr 2023
Hu Xinlin, Yang Ping, Chai Changdong, Liu Jia, Sun Huanhuan, Wu Yanan, Zhang Mingjie, Zhang Min, Liu Xiaotian, Yu Hongjun
Abstract excerpt
The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall1,2. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp3,4. Unfortunately, the mechanism of action of FKS remains enigmatic and this has hampered development of more effective medicines targeting the enzyme. Here we present the cryo-electron...
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