Article

Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance?

2025-05-13

Abstract excerpt

Echinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported. While resistance typically arises through mutations in Fks hotspots, emerging evidence suggests a contributing role of changes in membrane sterol composition due to ERG3 mutations. Here, we present a clinical case of Nakaseomyces glabratus ( Candida...

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Literature Corpus work: e0925cdb-9724-5482-8fe1-5acdf5d30cc7
DOI: 10.1101/2025.05.08.652905

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