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Article

Inhibition mechanism of the fungal β-1,3-glucan synthases by triterpenoid antifungal drugs.

Nature communications - 4 Feb 2026

You Zi-Long, Sun Lei, Wang Le-Xuan, Ni Yue-Ran, Lyu Rui-Qing, Chen Dan-Dan, Yun Cai-Hong, Song Tiefeng, Song Yinggai, Bai Lin

Abstract excerpt

β-1,3-glucan synthase is the molecular target for triterpenoid and echinocandin antifungal drugs in clinical. It catalyzes the formation of β-1,3-glucan, which is the primary component of the fungal cell wall. However, the inhibition mechanism of β-1,3-glucan synthase by triterpenoid drugs remains unclear. In this study, we report cryo-electron microscopy (cryo-EM) structures of Saccharomyces cerevisiae...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41639077
DOI: 10.1038/s41467-026-69114-8
PMCID: PMC12979857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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