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Article

Slt2 kinase of the cell wall integrity pathway is required for Fks2-specific echinocandin resistance in Candida glabrata.

Microbiology spectrum - 1 Sept 2026

Uddin Zubayeda, Tahsin Saira, Valickova Klara, Long Tengfei, Fruhauf De Macedo Laura, Popencuk Gabrielle, Zhao Yanan, Healey Kelley R

Abstract excerpt

Candida glabrata is an opportunistic yeast that causes invasive infections in immunocompromised individuals. Echinocandin antifungals are first-line agents in the treatment of invasive candidiasis and act by inhibiting fungal cell wall synthesis by targeting β-1,3-glucan synthase. Echinocandin resistance is primarily associated with mutations in FKS1 or FKS2, which encode for the catalytic subunit (Fks1 or Fks2)...

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Topics

Candida glabrata
Echinocandins
Cell Wall
Antifungal Agents
Drug Resistance, Fungal
Glucosyltransferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Fungal Proteins

Microbial Sensitivity Tests

Mutation

Humans

Source

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Identifiers

PMID: 42573236
DOI: 10.1128/spectrum.03874-25
PMCID: PMC13532262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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