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Functional analysis of the Candida albicans kinome reveals Hrr25 as a regulator of antifungal susceptibility

18 May 2022

Abstract excerpt

Candida albicans is a leading cause of death due to systemic fungal infections. Poor patient outcomes are attributable to the limited number of antifungal classes and the increasing prevalence of drug resistance. Protein kinases have emerged as rewarding targets in the development of drugs for diverse diseases, yet kinases remain untapped in the quest for new antifungals. Here, we performed a comprehensive...

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PMID: 35663022
DOI: 10.1016/j.isci.2022.104432

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