Article

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

2023-03-29

Abstract excerpt

Catalytic signaling outputs of protein kinases are dynamically regulated by an array of structural mechanisms, including allosteric interactions mediated by intrinsically disordered segments flanking the conserved catalytic domain. The Doublecortin Like Kinases (DCLKs) are a family of microtubule-associated proteins characterized by a flexible C-terminal autoregulatory ‘tail’ segment that varies in length across t...

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Literature Corpus work: 377edf34-fe87-5260-a390-ef9a4757c491
DOI: 10.1101/2023.03.29.534689

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