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Article

Molecular Mechanism of Mutational Disruption of DCLK1 Autoinhibition Provides a Rationale for Inhibitor Screening.

International journal of molecular sciences - 13 Sept 2023

Chen Weizhi, Liu Rui, Yu Yamei, Wei Dongqing, Chen Qiang, Xu Qin

Abstract excerpt

Doublecortin-like kinase 1 (DCLK1) is a prominent kinase involved in carcinogenesis, serving as a diagnostic marker for early cancer detection and prevention, as well as a target for cancer therapy. Extensive research efforts have been dedicated to understanding its role in cancer development and designing selective inhibitors. In our previous work, we successfully determined the crystal structure of DCLK1 while...

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Identifiers

PMID: 37762326
DOI: 10.3390/ijms241814020
PMCID: PMC10531055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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