Article
The DC-module of doublecortin: dynamics, domain boundaries, and functional implications.
Proteins - 1 Sept 2006
Cierpicki Tomasz, Kim Myung Hee, Cooper David R, Derewenda Urszula, Bushweller John H, Derewenda Zygmunt S
Abstract excerpt
The doublecortin-like (DC) domains, which usually occur in tandem, constitute novel microtubule-binding modules. They were first identified in doublecortin (DCX), a protein expressed in migrating neurons, and in the doublecortin-like kinase (DCLK). They are also found in other proteins, including the RP1 gene product which-when mutated-causes a form of inherited blindness. We previously reported an X-ray...
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