Article
Autoregulatory control of microtubule binding in doublecortin-like kinase 1.
eLife - 26 Jul 2021
Agulto Regina L, Rogers Melissa M, Tan Tracy C, Ramkumar Amrita, Downing Ashlyn M, Bodin Hannah, Castro Julia, Nowakowski Dan W, Ori-McKenney Kassandra M
Abstract excerpt
The microtubule-associated protein, doublecortin-like kinase 1 (DCLK1), is highly expressed in a range of cancers and is a prominent therapeutic target for kinase inhibitors. The physiological roles of DCLK1 kinase activity and how it is regulated remain elusive. Here, we analyze the role of mammalian DCLK1 kinase activity in regulating microtubule binding. We found that DCLK1 autophosphorylates a residue within...
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