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Article

Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1.

Structure (London, England : 1993) - 6 Sept 2016

Patel Onisha, Dai Weiwen, Mentzel Mareike, Griffin Michael D W, Serindoux Juliette, Gay Yoann, Fischer Stefanie, Sterle Shoukat, Kropp Ashleigh, Burns Christopher J, Ernst Matthias, Buchert Michael, Lucet Isabelle S

Abstract excerpt

Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that belongs to the family of microtubule-associated proteins. Originally identified for its role in neurogenesis, DCLK1 has recently been shown to regulate biological processes outside of the CNS. DCLK1 is among the 15 most common putative driver genes for gastric cancers and is highly mutated across various other human cancers. However, our present...

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Identifiers

PMID: 27545623
DOI: 10.1016/j.str.2016.07.008

Genes

DCLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1.PMID 27545623Read ↗

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Molecular Mechanism of Mutational Disruption of DCLK1 Autoinhibition Provides a Rationale for Inhibitor Screening.Semantic proximity Read ↗

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinasesSemantic proximity Read ↗

The DCX-domain tandems of doublecortin and doublecortin-like kinase.Semantic proximity Read ↗

The kinase activity of the cancer stem cell marker DCLK1 drives gastric cancer progression by reprogramming the stromal tumor landscapeSemantic proximity Read ↗

CMGC Kinases in Health and CancerSemantic proximity Read ↗

In silico analysis of human NEK10 reveals novel domain architecture and protein-protein interactionsSemantic proximity Read ↗

The DC-module of doublecortin: dynamics, domain boundaries, and functional implications.Semantic proximity Read ↗

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DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression.Semantic proximity Read ↗

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