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Article

Unveiling the Complexity of cis-Regulation Mechanisms in Kinases: A Comprehensive Analysis.

Proteins - 1 Mar 2025

Navarro Alvaro M, Alonso Macarena, Martínez-Pérez Elizabeth, Lazar Tamas, Gibson Toby J, Iserte Javier A, Tompa Peter, Marino-Buslje Cristina

Abstract excerpt

Protein cis-regulatory elements (CREs) are regions that modulate the activity of a protein through intramolecular interactions. Kinases, pivotal enzymes in numerous biological processes, often undergo regulatory control via inhibitory interactions in cis. This study delves into the mechanisms of cis regulation in kinases mediated by CREs, employing a combined structural and sequence analysis. To accomplish this,...

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PMID: 39366918
DOI: 10.1002/prot.26751

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