Article
A Regulatory Element in the Intrinsically Disordered C-Terminal Region of LMTK3 Modulates Its Kinase Domain Interactions and Breast Cancer Phenotypes.
Cells - 17 Aug 2026
Lauer Betrán Andrea, Agnarelli Alessandro, Samuels Mark, Vella Viviana, Shirazi Nia Reza, De Vega Daniel, Poudine Niloufar, Carter-Lopez Daniela, Ditsiou Angeliki, Eravci Murat, Prodromou Chrisostomos, Mancini Erika J, Giamas Georgios
Abstract excerpt
Lemur tail kinase 3 (LMTK3) is an oncogenic Ser/Thr kinase implicated in breast cancer (BC) progression, therapy resistance, and poor clinical outcomes, yet the molecular mechanisms governing its regulation remain poorly understood, particularly the role of its C-terminal intrinsically disordered region (IDR). Given that IDRs frequently harbour hidden structural motifs that control protein dynamics, we combined...
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