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Article

Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1.

Proceedings of the National Academy of Sciences of the United States of America - 8 Oct 2024

Harold Rachel L, Tulsian Nikhil K, Narasimamurthy Rajesh, Yaitanes Noelle, Ayala Hernandez Maria G, Lee Hsiau-Wei, Crosby Priya, Tripathi Sarvind M, Virshup David M, Partch Carrie L

Abstract excerpt

Casein kinase 1δ (CK1δ) controls essential biological processes including circadian rhythms and wingless-related integration site (Wnt) signaling, but how its activity is regulated is not well understood. CK1δ is inhibited by autophosphorylation of its intrinsically disordered C-terminal tail. Two CK1 splice variants, δ1 and δ2, are known to have very different effects on circadian rhythms. These variants differ...

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PMID: 39356670
DOI: 10.1073/pnas.2415567121
PMCID: PMC11474029

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