Comparison of the CDC2-like kinase family across eukaryotes highlights the functional conservation of these unique biological thermometers

Abstract excerpt

The family of CDC2-like kinases (CLKs) play a crucial role in regulating alternative splicing (AS), a process fundamental to eukaryotic gene expression and adaptation. Of particular interest, these enzymes exhibit unique responsiveness to minor temperature shifts, enabling them to modulate AS accordingly. Dysregulated CLK expression is linked to a wide variety of human diseases, establishing them as promising ther...

Topics

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• Adenosine Triphosphate
• Binding Sites
• Cancer-related Molecular Pathways
• Microtubule and mitosis dynamics
• Protein Conformation
• Protein Kinases
• Protein Processing, Post-Translational
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

5501a4ba-6e4f-5791-a354-09afe680cdd8

DOI

10.1101/2024.06.21.599975