Article

Extending differential gene expression testing to handle genome aneuploidy in cancer

2025-04-03

Abstract excerpt

Genome aneuploidy, characterized by copy number variations (CNVs), profoundly alters gene expression in cancer through direct gene dosage effects and indirect compensatory regulatory mechanisms. However, existing differential gene expression (DGE) testing methods do not differentiate between these mechanisms, conflating all expression changes, limiting biological interpretability and obscuring key genes involved i...

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Literature Corpus work: 375bea47-b0ad-50cd-9acc-a0a2f566ef1a
DOI: 10.1101/2025.03.29.646108

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