Article

DeepCNA: an explainable deep learning method for cancer diagnosis and cancer-specific patterns of copy number aberrations

2024-03-13

Abstract excerpt

Chromosomal instability leads to an increased rate of chromosome or part-chromosome copy gains or losses. Referred to as chromosome copy aberrations (CNAs), these mutations are highly prevalent in cancer cells and contribute to abnormal genome structure, genetic diversity within a tumour, drug resistance, and evolution to metastatic disease. Within each cancer type, it remains unclear how CNAs define each particul...

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Literature Corpus work: e15868a7-50d3-568c-b497-f857ec4ebc5d
DOI: 10.1101/2024.03.08.584160

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