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Article

Penalized regression elucidates aberration hotspots mediating subtype-specific transcriptional responses in breast cancer.

Bioinformatics (Oxford, England) - 1 Oct 2011

Yuan Yinyin, Rueda Oscar M, Curtis Christina, Markowetz Florian

Abstract excerpt

MOTIVATION: Copy number alterations (CNAs) associated with cancer are known to contribute to genomic instability and gene deregulation. Integrating CNAs with gene expression helps to elucidate the mechanisms by which CNAs act and to identify the transcriptional downstream targets of CNAs. Such analyses can help to sort functional driver events from the many accompanying passenger alterations. However, the way...

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PMID: 21804112
DOI: 10.1093/bioinformatics/btr450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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