Article

Contrastive Alignment of Expression and Copy Number Highlights Dosage-Insensitive Genes in Cancer

2026-03-03

Abstract excerpt

Copy number variations (CNVs) are a hallmark of cancer genomes, yet the relationship between CNV and gene expression is not strictly deterministic. Some genes maintain stable expression despite copy number changes through regulatory compensation. Identifying these dosage-insensitive genes is challenging, requiring methods that distinguish true regulatory escape from technical noise in heterogeneous single-cell dat...

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Literature Corpus work: a0066a86-d0ad-5823-b031-fadf4ceb24f6
DOI: 10.64898/2026.03.01.708901

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