Article
Transcriptional effects of copy number alterations in a large set of human cancers.
Nature communications - 5 Feb 2020
Bhattacharya Arkajyoti, Bense Rico D, Urzúa-Traslaviña Carlos G, de Vries Elisabeth G E, van Vugt Marcel A T M, Fehrmann Rudolf S N
Abstract excerpt
Copy number alterations (CNAs) can promote tumor progression by altering gene expression levels. Due to transcriptional adaptive mechanisms, however, CNAs do not always translate proportionally into altered expression levels. By reanalyzing >34,000 gene expression profiles, we reveal the degree of transcriptional adaptation to CNAs in a genome-wide fashion, which strongly associate with distinct biological...
Topics
- Biopsy
- CD8-Positive T-Lymphocytes
- DNA Copy Number Variations
- Databases, Factual
- Gene Expression Regulation, Neoplastic
- Humans
- Neoplasms
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- Transcription, Genetic