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Article

Inferring causal genomic alterations in breast cancer using gene expression data.

BMC systems biology - 1 Aug 2011

Tran Linh M, Zhang Bin, Zhang Zhan, Zhang Chunsheng, Xie Tao, Lamb John R, Dai Hongyue, Schadt Eric E, Zhu Jun

Abstract excerpt

BACKGROUND: One of the primary objectives in cancer research is to identify causal genomic alterations, such as somatic copy number variation (CNV) and somatic mutations, during tumor development. Many valuable studies lack genomic data to detect CNV; therefore, methods that are able to infer CNVs from gene expression data would help maximize the value of these studies. RESULTS: We developed a framework for...

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Identifiers

PMID: 21806811
DOI: 10.1186/1752-0509-5-121
PMCID: PMC3162519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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