Article

Multi-ethnic polygenic risk modifies the association between <i>APOL1</i> high risk genotypes and chronic kidney disease

2021-11-14

Abstract excerpt

The burden of advanced chronic kidney disease (CKD) falls disproportionately on minorities including African Americans (AAs) and Hispanic Americans (HAs) with admixed ancestry. Even though APOL1 high-risk genotypes increase risk of kidney disease, their penetrance is incomplete, indicating that the modification of APOL1 high risk may be polygenic. For this study, we used three multi-ethnic cohorts with APOL1 high...

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Literature Corpus work: 374f6d7e-bd98-591d-81d6-d69faf459a70
DOI: 10.1101/2021.11.12.21266238

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