Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and Genetic Characteristics of CKD Patients with High-Risk APOL1 Genotypes.

Journal of the American Society of Nephrology : JASN - 1 May 2023

Elliott Mark D, Marasa Maddalena, Cocchi Enrico, Vena Natalie, Zhang Jun Y, Khan Atlas, Krishna Murthy Sarath, Bheda Shiraz, Milo Rasouly Hila, Povysil Gundula, Kiryluk Krzysztof, Gharavi Ali G

Abstract excerpt

SIGNIFICANCE STATEMENT: APOL1 high-risk genotypes confer a significant risk of kidney disease, but variability in patient outcomes suggests the presence of modifiers of the APOL1 effect. We show that a diverse population of CKD patients with high-risk APOL1 genotypes have an increased lifetime risk of kidney failure and higher eGFR decline rates, with a graded risk among specific high-risk genotypes. CKD patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein L1
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Inflammasomes

Share to Renal Diseases and Glomerulopathies

Share to Renal Insufficiency, Chronic

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 36758113
DOI: 10.1681/ASN.0000000000000094
PMCID: PMC10125632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and Genetic Characteristics of CKD Patients with High-Risk APOL1 Genotypes.PMID 36758113Read ↗

Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.Semantic proximity Read ↗

Prevalence of Mendelian kidney disease among patients with high-risk<i>APOL1</i>genotypes undergoing commercial genetic testing in the United StatesSemantic proximity Read ↗

Phenome-wide analysis reveals epistatic associations between APOL1 variants and chronic kidney disease and multiple other disorders.Semantic proximity Read ↗

APOL1 Kidney Risk Variants and Proteomics.Semantic proximity Read ↗

APOL1-associated kidney disease: modulators of the genotype-phenotype relationship.Semantic proximity Read ↗

Multi-ethnic polygenic risk modifies the association between <i>APOL1</i> high risk genotypes and chronic kidney diseaseSemantic proximity Read ↗

APOL1 and APOL1-Associated Kidney Disease: A Common Disease, an Unusual Disease Gene – Proceedings of the Henry Shavelle ProfessorshipSemantic proximity Read ↗

Beyond Genotype: Multidomain Biomarker-Integrated Risk Scores Reveal Prognostic phenotypes Among Individuals with High-Risk <i>APOL1</i> GenotypesSemantic proximity Read ↗

Population genetics of chronic kidney disease: the evolving story of APOL1.Semantic proximity Read ↗

Genetics of kidney failure and the evolving story of APOL1.Semantic proximity Read ↗

"Biomarking" the transition from genetic risk to kidney disease.Semantic proximity Read ↗

Genome-Wide Polygenic Risk Score for CKD in Individuals with APOL1 High-Risk Genotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.