Population-based risk assessment of APOL1 on renal disease.

Abstract excerpt

Case-control studies suggest that African Americans with genetic variants in both copies of APOL1 have increased risk for hypertension-attributable ESRD and focal segmental glomerulosclerosis. Here, we tested these risk variants in the Dallas Heart Study to ascertain the prevalence of APOL1-associated renal disease in a large population-based study and to estimate the contribution of APOL1 risk variants to...

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• Apolipoprotein L1
• Apolipoproteins
• Black or African American
• Diabetes Mellitus
• Haploidy