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Phenome-wide analysis reveals epistatic associations between APOL1 variants and chronic kidney disease and multiple other disorders.

EBioMedicine - 1 Mar 2024

Adamson Walt E, Noyes Harry, Johnson Paul, Cooper Anneli, Monckton Darren G, Ogunsola John, Beckett-Hill Georgia, Sullivan Michael, Mark Patrick, Parekh Rulan S, MacLeod Annette

Abstract excerpt

BACKGROUND: APOL1 variants G1 and G2 are common in populations with recent African ancestry. They are associated with protection from African sleeping sickness, however homozygosity or compound heterozygosity for these variants is associated with chronic kidney disease (CKD) and related conditions. What is not clear is the extent of associations with non-kidney-related disorders, and whether there are clusters of...

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Apolipoprotein L1
Apolipoproteins
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Renal Insufficiency, Chronic

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PMID: 38360481
DOI: 10.1016/j.ebiom.2024.105000
PMCID: PMC10944146

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