KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.

doi:10.1038/s41467-026-69367-3

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KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.

Nature communications - 10 Feb 2026

Kamiza Abram B, Chikowore Tinashe, Chen Guanjie, Ojewunmi Oyesola, Machipisa Tafadzwa, Zhou Feng, Mayanja Richard, Toure Sounkou, Soremekun Opeyemi, Kintu Christopher, Nakabuye Mariam, Koprulu Mine, Kalungi Allan, Kalyesubula Robert, Salako Babatunde, Nashiru Oyekanmi, Corpas Manuel, Robinson-Cohen Cassianne, Franceschini Nora, Pattaro Cristian, Köttgen Anna, Nitsch Dorothea, Langenberg Claudia, Tcheandjieu Catherine, Nyirenda Moffat, Morris Andrew P, Asimit Jennifer, Zeggini Eleftheria, Rotimi Charles, Ramsay Michele, Adeyemo Adebowale, Fabian June, Crampin Amelia C, Brandenburg Jean-Tristan, Fatumo Segun

Abstract excerpt

Kidney disease disproportionately affects populations of African ancestry, yet most genetic studies have focused on Europeans. Here, we present a three-stage genome-wide association study meta-analysis of estimated glomerular filtration rate in ~26,000 individuals across Eastern, Western, and Southern Africa and ~81,000 African-ancestry individuals in the diaspora. Continental African meta-analysis identifies...

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PMID: 41667462
DOI: 10.1038/s41467-026-69367-3
PMCID: PMC13003101

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