Article
Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.
Kidney international - 1 May 2020
Bajaj Archna, Ihegword Andrea, Qiu Chengxiang, Small Aeron M, Wei Wei-Qi, Bastarache Lisa, Feng QiPing, Kember Rachel L, Risman Marjorie, Bloom Roy D, Birtwell David L, Williams Heather, Shaffer Christian M, Chen Jinbo, Center Regeneron Genetics, Denny Joshua C, Rader Daniel J, Stein C Michael, Damrauer Scott M, Susztak Katalin
Abstract excerpt
The relationship between commonly occurring genetic variants (G1 and G2) in the APOL1 gene in African Americans and different disease traits, such as kidney disease, cardiovascular disease, and pre-eclampsia, remains the subject of controversy. Here we took a genotype-first approach, a phenome-wide association study, to define the spectrum of phenotypes associated with APOL1 high-risk variants in 1,837 African...
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