Article

Cognitively healthy centenarians are characterized by lower frequencies of six disease-associated<i>HLA</i>alleles

2025-03-31

Abstract excerpt

<h4>Background</h4> Human leukocyte antigen ( HLA ) genes are key regulators of immune function and have been implicated in susceptibility to various diseases. However, their role in healthy longevity remains unclear. Here, we investigate the relationship between disease-associated HLA alleles and the likelihood of becoming a cognitively healthy centenarian (CHC). <h4>Methods</h4> We imputed HLA genotypes using ge...

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Literature Corpus work: e5423491-a7ac-5041-b925-0f9a1957f141
DOI: 10.1101/2025.03.30.25324899

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