Article

3S-DB Identifies an RNA Repository Facilitating Stop Codon Readthrough for Selenocysteine Insertion and Selenoproteome Expansion

2025-06-17

Abstract excerpt

<title>Abstract</title> <p>Selenoproteins are proteins that contain selenocysteine (Sec, U), the 21st amino acid, whose highly reactive selenol group makes these proteins essential for redox regulation. Sec is incorporated via a stop codon readthrough mechanism—a widespread, functionally essential, and tightly regulated mode of gene expression. This process primarily involves the UGA stop codon, the SECIS RNA ele...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3734b433-12a5-50ae-bde8-f9fc6bf9aae0
DOI: 10.21203/rs.3.rs-6900872/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

3S-DB Identifies an RNA Repository Facilitating Stop Codon Readthrough for Selenocysteine Insertion and Selenoproteome ExpansionDOI 10.21203/rs.3.rs-6900872/v1Read

Characterization of Mammalian SelenoproteomesSemantic proximity Read

The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding.Semantic proximity Read

Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2.Semantic proximity Read

Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2.Semantic proximity Read

Regulatory start-stop elements in 5’ untranslated regions pervasively modulate translationSemantic proximity Read

A novel protein domain induces high affinity selenocysteine insertion sequence binding and elongation factor recruitment.Semantic proximity Read

Efficient incorporation of multiple selenocysteines involves an inefficient decoding step serving as a potential translational checkpoint and ribosome bottleneck.Semantic proximity Read

Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2.Semantic proximity Read

RNA Sequencing Reveals Divergent Transcriptome Changes in SBP2 and SECISBP2L Depleted Cell LinesSemantic proximity Read

Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements.Semantic proximity Read

SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans.Semantic proximity Read

Mechanism and regulation of selenoprotein synthesis.Semantic proximity Read