Article

RNA Sequencing Reveals Divergent Transcriptome Changes in SBP2 and SECISBP2L Depleted Cell Lines

2025-07-03

Abstract excerpt

Selenocysteine (Sec), the 21st amino acid, is co-translationally inserted at UGA codons via a specialized machinery requiring SECIS elements, Sec-tRNA^Sec, eEFSec, and SECIS-binding protein 2 (SBP2). While SBP2 is essential for Sec incorporation in vitro and in vivo, the function of its paralog, SECISBP2L, remains incompletely defined. In this study, we investigated the distinct roles of SBP2 and SECISBP2L in the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80eb7fd1-eb08-5163-a431-28bdf7bc4655
DOI: 10.1101/2025.07.02.662884

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA Sequencing Reveals Divergent Transcriptome Changes in SBP2 and SECISBP2L Depleted Cell LinesDOI 10.1101/2025.07.02.662884Read

Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2.Semantic proximity Read

Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2.Semantic proximity Read

The emerging role of selenium metabolic pathways in cancer: New therapeutic targets for cancerSemantic proximity Read

3S-DB Identifies an RNA Repository Facilitating Stop Codon Readthrough for Selenocysteine Insertion and Selenoproteome ExpansionSemantic proximity Read

<i>SECISBP2</i> Deficiency Causes a Lethal Perinatal CardiomyopathySemantic proximity Read

A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium.Semantic proximity Read

Secisbp2 is essential for embryonic development and enhances selenoprotein expression.Semantic proximity Read

Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2.Semantic proximity Read

Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements.Semantic proximity Read

Selenoprotein-related disease in a young girl caused by nonsense mutations in the SBP2 gene.Semantic proximity Read

Characterization of Mammalian SelenoproteomesSemantic proximity Read

A Novel Homozygous Selenocysteine Insertion Sequence Binding Protein 2 (SECISBP2, SBP2) Gene Mutation in a Turkish BoySemantic proximity Read