Article
Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2.
The Journal of biological chemistry - 30 Nov 2007
Bubenik Jodi L, Driscoll Donna M
Abstract excerpt
The expression of selenoproteins requires the translational recoding of the UGA stop codon to selenocysteine. In eukaryotes, this requires an RNA stem loop structure in the 3'-untranslated region, termed a selenocysteine insertion sequence (SECIS), and SECIS-binding protein 2 (SBP2). This study implicates SBP2 in dictating the hierarchy of selenoprotein expression, because it is the first to show that SBP2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.