Article
A novel protein domain induces high affinity selenocysteine insertion sequence binding and elongation factor recruitment.
The Journal of biological chemistry - 12 Dec 2008
Donovan Jesse, Caban Kelvin, Ranaweera Ruchira, Gonzalez-Flores Jonathan N, Copeland Paul R
Abstract excerpt
Selenocysteine (Sec) is incorporated at UGA codons in mRNAs possessing a Sec insertion sequence (SECIS) element in their 3'-untranslated region. At least three additional factors are necessary for Sec incorporation: SECIS-binding protein 2 (SBP2), Sec-tRNA(Sec), and a Sec-specific translation elongation factor (eEFSec). The C-terminal half of SBP2 is sufficient to promote Sec incorporation in vitro, which is...
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