Article
Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2.
RNA biology - 1 Jan 2000
Bubenik Jodi L, Ladd Andrea N, Gerber Carri A, Budiman Michael E, Driscoll Donna M
Abstract excerpt
The human selenoproteome is composed of approximately 25 selenoproteins, which cotranslationally incorporate selenocysteine, the 21st amino acid. Selenoprotein expression requires an unusual translation mechanism, as selenocysteine is encoded by the UGA stop codon. SECIS-binding protein 2 (SBP2) is an essential component of the selenocysteine insertion machinery. SBP2 is also the only factor known to...
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