Article
Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2.
RNA biology - 1 Jan 2014
Bubenik Jodi L, Miniard Angela C, Driscoll Donna M
Abstract excerpt
Selenium, a micronutrient, is primarily incorporated into human physiology as selenocysteine (Sec). The 25 Sec-containing proteins in humans are known as selenoproteins. Their synthesis depends on the translational recoding of the UGA stop codon to allow Sec insertion. This requires a stem-loop structure in the 3' untranslated region of eukaryotic mRNAs known as the Selenocysteine Insertion Sequence (SECIS). The...
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