Article
Efficient incorporation of multiple selenocysteines involves an inefficient decoding step serving as a potential translational checkpoint and ribosome bottleneck.
Molecular and cellular biology - 1 Dec 2006
Stoytcheva Zoia, Tujebajeva Rosa M, Harney John W, Berry Marla J
Abstract excerpt
Selenocysteine is incorporated into proteins via "recoding" of UGA from a stop codon to a sense codon, a process that requires specific secondary structures in the 3' untranslated region, termed selenocysteine incorporation sequence (SECIS) elements, and the protein factors that they recruit. Whereas most selenoprotein mRNAs contain a single UGA codon and a single SECIS element, selenoprotein P genes encode...
Topics
- Animals
- Cell Line
- Codon
- Codon, Terminator
- Evolution, Molecular
- Humans
- Mutation
- Protein Biosynthesis
- RNA Precursors
- Ribosomes
- Selenocysteine
- Selenoprotein P
- Sequence Deletion
- Zebrafish
- Zebrafish Proteins