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Article

Mechanism and regulation of selenoprotein synthesis.

Annual review of nutrition - 1 Jan 2003

Driscoll Donna M, Copeland Paul R

Abstract excerpt

Selenium is an essential trace element that is incorporated into proteins as selenocysteine (Sec), the twenty-first amino acid. Sec is encoded by a UGA codon in the selenoprotein mRNA. The decoding of UGA as Sec requires the reprogramming of translation because UGA is normally read as a stop codon. The translation of selenoprotein mRNAs requires cis-acting sequences in the mRNA and novel trans-acting factors...

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Identifiers

PMID: 12524431
DOI: 10.1146/annurev.nutr.23.011702.073318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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