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Article

Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements.

Open biology - 1 Nov 2016

Wu Sen, Mariotti Marco, Santesmasses Didac, Hill Kristina E, Baclaocos Janinah, Aparicio-Prat Estel, Li Shuping, Mackrill John, Wu Yuanyuan, Howard Michael T, Capecchi Mario, Guigó Roderic, Burk Raymond F, Atkins John F

Abstract excerpt

Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3' UTR structural elements (SECIS) and is regulated by selenium availability. In addition to the previously known human Sepp1 mRNA poly(A) addition site just 3' of SECIS 2, two further sites were identified with one resulting in 10-25% of the mRNA lacking SECIS 2. To...

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Identifiers

PMID: 27881738
DOI: 10.1098/rsob.160241
PMCID: PMC5133445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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