Article

Evolution Inspired Engineering of Megasynthetases

2022-12-02

Abstract excerpt

Many clinically used drugs are derived from or inspired by bacterial natural products that often are biosynthesised via non-ribosomal peptide synthetases (NRPS), giant megasynthases that activate and join individual amino acids in an assembly line fashion. Since NRPS are not limited to the incorporation of the 20 proteinogenic amino acids, their efficient manipulation would allow the biotechnological generation of...

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Literature Corpus work: 36d59f48-effd-5576-9224-4e8c06acb2e2
DOI: 10.1101/2022.12.02.518901

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