Article
Natural noncanonical protein splicing yields products with diverse β-amino acid residues.
Science (New York, N.Y.) - 16 Feb 2018
Morinaka Brandon I, Lakis Edgars, Verest Marjan, Helf Maximilian J, Scalvenzi Thibault, Vagstad Anna L, Sims James, Sunagawa Shinichi, Gugger Muriel, Piel Jörn
Abstract excerpt
Current textbook knowledge holds that the structural scope of ribosomal biosynthesis is based exclusively on α-amino acid backbone topology. Here we report the genome-guided discovery of bacterial pathways that posttranslationally create β-amino acid-containing products. The transformation is widespread in bacteria and is catalyzed by an enzyme belonging to a previously uncharacterized radical...
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